Cd72 (CD72.1 alloantigen) Mouse Monoclonal Antibody [Clone ID: 10-1.D.2]

Specifications

Product Data
Clone Name	10-1.D.2
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1,2)
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	DBA/2 mouse spleen cells. (Ref.1)
Specificity	This antibody recognises CD72.1/Lyb-2.1 (Mr. 45 kDa).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD72 antigen
Database Link	Entrez Gene 12517 Mouse UniProt ID P21855
Background	Murine CD72.1/Lyb-2.1, a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 (Ly-1) which is distributed on all T cells and a small number of B cells. (Ref.1,2) This clone blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. (Ref.1) However, 10-1.D.2 can itself trigger a positive signal by binding CD72. (Ref.1-5)
Synonyms	Lyb-2, Ly-32, Ly32, B-Cell marker
Reference Data

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