CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]

CAT#: AM03092RP-N

CD105 (ENG) mouse monoclonal antibody, clone MEM-229, PE

Conjugation: Unconjugated Biotin FITC PE



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CNY 4,340.00


货期*
5周

规格
    • 100 Tests

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Specifications

Product Data
Clone Name MEM-229
Applications FC, IF
Recommend Dilution Flow Cytometry analysis of Human blood cells using 20 µl reagent/100 µl of whole blood or 10e6 cells in a suspension.
Reactivity Human, Porcine
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA
Specificity This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. 
Negative Species: Canine (Dog), Equine (Horse).
Formulation Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2% (w/v) high-grade protease free BSA as a stabilizing agent.
Label: PE
State: Liquid purified Ig fraction
Label: Conjugated with R-Phycoerythrin
Purification Size-Exclusion Chromatography
Conjugation PE
Storage Condition Store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Gene Name endoglin
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms ENG, END, HHT1, ORW, ORW1
Note The content of a vial (2 ml) is sufficient for 25 tests.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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