CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]

CAT#: AM03092PU-N

CD105 (ENG) mouse monoclonal antibody, clone MEM-229, Purified

Conjugation: Unconjugated Biotin FITC PE



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CNY 3,280.00


货期*
5周

规格
    • 100 ug

Cited in 4 publications.

Product images

Specifications

Product Data
Clone Name MEM-229
Applications FC, IF, IHC, WB
Recommend Dilution Flow Cytometry: 10 μg/ml. 
Positive Control: Kg1 Human acute myelogenous leukemia cell line.
Western Blotting (Non-Reducing Conditions).
Immunocytochemistry. 
Immunohistochemistry on Frozen Sections: 1/200 (Acetone Fixation).
Reactivity Human, Porcine
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
Specificity The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Formulation PBS, pH~7.4
State: Purified
State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration lot specific
Purification Protein-A Affinity Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name endoglin
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms ENG, END, HHT1, ORW, ORW1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (4)

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