Human IL6: A Pleiotropic Inflammatory Cytokine

Jul 11, 2022

Human IL6: A Pleiotropic Inflammatory Cytokine

Interleukin 6 (IL-6) is a pleiotropic cytokine. It plays important role in inflammation disorders, autoimmune diseases, obesity, and cancer. Levels of IL-6 in human blood are very low under normal conditions, but the levels can increase thousands-fold in inflammatory states. Thus, monitoring IL-6 levels can help in diagnosing and preventing infectious diseases.

IL-6 Signaling Pathway

IL-6 has both pro-and anti-inflammatory functions that are mediated by the soluble form of IL-6 receptor (sIL-6R; trans-signaling) and the membrane-bound IL-6R (classic signaling). Ligand-bound IL-6 receptors can assemble with the integral protein gp130 (IL6ST) to recruit non-receptor tyrosine kinases (e.g., JAK1) and activate STAT3.

acute-phase-proteins

IL-6 Resource Tool Center

Assay Kits for IL6

OriGene's IL6 ELISA kit provides sensitive and reliable IL-6 measurements to obtain valuable data from your experiments.

Get your IL-6 Elisa Kit here

IL-6 Standard Curve

Antibodies for IL6

OriGene has developed highly-specific and sensitive antibodies that recognize native epitopes which can be used in IHC, ELISA, WB. IF, IP etc

Primary Antibodies

TA500067

Cat# TA500067

IHC staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.

Carrier-Free Antibodies

CF500067

Cat# CF500067

IHC staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.

Primary Antibody Samples

TA500065S

Cat# TA500065S

IHC staining of paraffin-embedded Human prostate tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.

Clones for IL6

OriGene has developed expression ready plasmids and Lentiviral particles for various species such as human, mouse and rat species.

Tagged/Un-Tagged Clones

RC202078
Cat# RC202078

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY IL-6 (Cat# RC202078, Right lane) cDNA for 48 hrs and lysed

Lentiviral Particles

RC202078L4
Cat# RC202078L4

HEK293T cells were transduced with RC202078L4V particle to overexpress human IL6-mGFP fusion protein.

Other products for IL6