HER2

HER2 gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It is found in 10-30% of all breast cancers, 29% of gastric cancers, 10% of lung cancers, and 18-61% of uterine cancers.

• 10-30% of all breast cancers
• 29% of gastric cancers
• 10% of lung cancers
• 18-61% of uterine cancers

The diagram depicts HER2 amplification at the protein and DNA level.

HER2 UltraMab™ Antibody

The four panels show different levels of HER2 expression in FFPE human breast cancer. IHC was done on a breast cancer tissue microarray using mouse anti-HER2 clone UMAB36 (SKU# UM500036) monoclonal antibody (1:100). Anti-HER2 clone UMAB36 requires HIER pretreatment with Tris/EDTA pH 8.5 buffer for optimal staining. HER2 expression levels were evaluated by a board certified pathologist.

Immunofluorescence image of FFPE HER2+ breast cancer labeled with HER2 mouse monoclonal antibody clone UMAB36 (red, SKU# UM500036) and DAPI (blue) for nuclear staining.

Western blot analysis of HepG2, HeLa, A549, and MCF7 cell lines extracts (35ug per lane) using anti-HER2 antibody (clone UMAB36) at 1:500.