GDAP1L1 Human shRNA Plasmid Kit (Locus ID 78997)
CAT#: TR307250
GDAP1L1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 6,790.00
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | GDAP1L1 Human shRNA Plasmid Kit (Locus ID 78997) |
Locus ID | 78997 |
UniProt ID | Q96MZ0 |
Synonyms | dJ881L22.1; dJ995J12.1.1 |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | GDAP1L1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 78997). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | NM_001256737, NM_001256738, NM_001256739, NM_001256740, NM_024034, NR_046353, NM_024034.1, NM_024034.2, NM_024034.3, NM_024034.4, NM_001256738.1, NM_001256740.1, NM_001256739.1, NM_001256737.1, BC000199, BC000199.1, BC009014, NM_001256739.2, NM_024034.6 |
Summary | The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
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