CCN4 (NM_080838) Human Recombinant Protein
CAT#: TP761856
Purified recombinant protein of Human WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
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CNY 2,040.00
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length WISP1
|
Tag | N-GST and C-His |
Predicted MW | 56.3 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50 mM Tris-HCl, pH 8.0, 8 M urea |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_543028 |
Locus ID | 8840 |
UniProt ID | O95388 |
Refseq Size | 1035 |
Cytogenetics | 8q24.22 |
Refseq ORF | 840 |
Synonyms | WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc |
Summary | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] |
Protein Families | Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - Wnt Signaling pathway |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC403320 | WISP1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC418374 | WISP1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY403320 | Transient overexpression lysate of WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 2 |
CNY 3,080.00 |
|
LY418374 | Transient overexpression lysate of WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 1 |
CNY 3,080.00 |
|
PH310402 | WISP1 MS Standard C13 and N15-labeled recombinant protein (NP_003873) |
CNY 19,520.00 |
|
TP310402 | Recombinant protein of human WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 1, 20 µg |
CNY 2,900.00 |