BMP2 (NM_001200) Human Recombinant Protein
CAT#: TP750012
Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.
View other "BMP2" proteins (4)
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CNY 4,020.00
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding the region (Gln283-Arg396) of human BMP2
|
Tag | Tag Free |
Predicted MW | 13 kDa |
Concentration | Resuspend the protein to the desired concentration in proper buffer. |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a sterile solution containing 10 mM sodium citrate, pH 3.5 |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Bioactivity | Measured?by?its?ability?to?induce?alkaline?phosphatase?production in?ATDC5?cells. ED50 for this effect is typically 36 - 55 ng/ml. Co-immunoprecipitation (PMID: 28009989) |
Endotoxin | < 0.1 EU per 1 µg of the protein by the LAL |
Reference Data | |
RefSeq | NP_001191 |
Locus ID | 650 |
UniProt ID | P12643, C8C060 |
Refseq Size | 1547 |
Cytogenetics | 20p12.3 |
Refseq ORF | 1188 |
Synonyms | BDA2; BMP2A; SSFSC; SSFSC1 |
Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] |
Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane |
Protein Pathways | Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis
,Sun, J;Liu, X;Gao, H;Zhang, L;Ji, Q;Wang, Z;Zhou, L;Wang, Y;Sui, H;Fan, Z;Li, Q;,
Oncotarget
,PubMed ID 28009989
[BMP2]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400481 | BMP2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400481 | Transient overexpression lysate of bone morphogenetic protein 2 (BMP2) |
CNY 2,990.00 |
|
TP720011 | Recombinant protein of human bone morphogenetic protein 2 (BMP2), the domain of Gln283-Arg396 |
CNY 3,140.00 |
|
TP760521 | Purified recombinant protein of Human bone morphogenetic protein 2 (BMP2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
CNY 2,040.00 |