Recombinant Noggin，Mouse，HEK293

Specifications

Product Data
Species	Mouse
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence encoding Mouse Noggin(#P97466) (Met1-Cys232) was expressed with Human IgG1 Fc tag at the C-terminus.
Tag	Human IgG1 Fc Tag (C-term)
Predicted MW	The protein has a calculated MW of 49.14 kDa. The protein migrates as 50 kDa under reducing condition (SDS-PAGE analysis).
Purity	>95% as determined by SDS-PAGE.
Buffer	The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4.
Applications	Cell culture
Storage	Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.
Bioactivity	Testing in process
Endotoxin	<0.1 EU per 1 μg of the protein by the LAL method.
Reference Data
UniProt ID	P97466
Synonyms	Nog
Summary	Noggin binds members of the transforming Growth Factors-beta (TGF beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP-4), which inactivates their activities. As a extracellular antagonist of BMP proteins, Noggin involves in the development of many body tissues, including nerve tissue, muscles, and bones. In addition, Noggin is able to inhibit chondrocyte differentiation through its interaction with GDF5.

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