SARS-CoV-2 Recombinant Protein

Specifications

Product Data
Species	SARS-CoV-2
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln14-Arg685
Buffer	Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.
Note	Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed.
Storage	Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Synonyms	S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
Summary	Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.