CD22 Human Recombinant Protein

CAT#: TP727078

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-Fc)



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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经常一起买 (1)
CD22 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)
    • 100 ul

CNY 1,999.00
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Specifications

Product Data
Species Human
Protein Source Human
Expression cDNA Clone or AA Sequence
Tag C-Fc
Buffer Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl,150mM NaCl,1mM EDTA,pH 8.0.
Note Recombinant Human B-cell Receptor CD22 is produced by our Mammalian expression system and the target gene encoding Asp20-Arg687 is expressed with a Fc tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 933
UniProt ID P20273
Synonyms B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14
Summary Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Cell adhesion molecules (CAMs), Hematopoietic cell lineage
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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