St6galnac2 Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ser28-Arg373
Tag	C-His
Buffer	Supplied as a 0.2 um filtered solution of 50mMTris-HCl, 150mM NaCl, pH 7.5.
Note	Recombinant Mouse Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase 2 is produced by our Mammalian expression system and the target gene encoding Ser28-Arg373 is expressed with a 6His tag at the C-terminus.
Storage	Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	20446
UniProt ID	P70277
Synonyms	Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase,GalNAc alpha-2,6-sialyltransferase II,ST6GalNAc II,Sialyltransferase 7B,SIAT7-B
Summary	Alpha‑N‑acetylgalactosaminide alpha ‑2,6‑sialyltransferase 2, is a type II membrane protein localized in the Golgi network and catalyzes 2,6‑sialylation of the Tn antigen. Sialyl‑Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. it has been reported that disregulation of this gene is involved in the pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys (4). The enzyme may also be used to synthesize a cancer vaccine.

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