Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Met3-Phe483
Tag	C-His
Buffer	Filtered solution of 20 mM PB, 150 mM NaCl, pH6.0
Note	Recombinant Human Serine Hydroxymethyltransferase Cytosolic is produced by our Mammalian expression system and the target gene encoding Met3-Phe483 is expressed with a 6His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Synonyms	Serine Hydroxymethyltransferase Cytosolic; SHMT; Glycine Hydroxymethyltransferase; Serine Methylase; SHMT1
Summary	Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.

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