RBM20 Human Recombinant Protein
CAT#: TP725477
Recombinant Human RNA-binding protein 20/RBM20(C-His)
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CNY 3,140.00
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Specifications
Product Data | |
Species | Human |
Protein Source | E. coli |
Expression cDNA Clone or AA Sequence |
E931-L1227
|
Tag | C-His |
Buffer | Supplied as a 0.2 um filtered solution of 500mM PBS, 300mM NaCl, 10%Glycerol, pH7.4 |
Note | MADE TO ORDER | Recombinant Human RNA-binding protein 20/RBM20 is produced by E.coli expression system and the target gene encoding E931-L1227 is expressed with a His tag at the C-terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 282996 |
UniProt ID | Q5T481 |
Synonyms | RNA-binding motif protein 20 |
Summary | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH. Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts. RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles. RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts. Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes. |
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