Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ile24-Asp159
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Note	Recombinant Mouse Transforming Growth Factor-beta Receptor Type II is produced by our Mammalian expression system and the target gene encoding Ile24-Asp159 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Synonyms	TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-betareceptor type II; TGF-beta receptor type II; TbetaR-II; Tgfbr2
Summary	Transforming growth factor-beta receptor type II (TGF-β RII) contains a C-terminal protein kinase domain and an N-terminal ectodomain and is the member of the transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. TGF-β RII has a protein kinase domain that forms a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein can enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

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