P cadherin (CDH3) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Glu25-Gly654
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human Cadherin-3 is produced by our Mammalian expression system and the target gene encoding Glu25-Gly654 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	1001
UniProt ID	P22223
Summary	Cadherin-3 (CDH3), also known as placental cadherin, is a single-pass type I membrane protein that belongs to the cadherin superfamily. CDH3 is expressed in some normal epithelial tissues and some carcinoma cell lines. CDH3 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. It preferentially binds to one another in a homophilic manner. CDH3 plays a role in development, specifically in tissue formation. CDH3 is also involved in the loss of heterozygosity events in breast and prostate cancer. Mutations in CDH3 have been associated with congenital hypotrichosis with juvenile macular dystrophy.

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