RBP4 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) E19-L201
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.2
Note	Recombinant Human Retinol-Binding Protein 4 is produced by Human 293 Cells. The target gene encoding E19-L201 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	5950
UniProt ID	P02753
Synonyms	Plasma retinol-binding protein; RBP4; retinol binding protein 4, plasma; RetinolBinding Protein 4; retinol-binding protein 4
Summary	Retinol-binding protein 4 (RBP4) is a prototypic member of the lipocalin superfamily. RBP4 acts as a carrier for retinol (vitamin A), can stabilize the unstable and insoluble retinol in aqueous solution through their tight interaction. RBP4 is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), which is crucial for preventing RBP4 excretion through the kidney glomeruli. Recently studies found that RBP4 is expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).
Protein Families	Druggable Genome, Secreted Protein

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