Il12b Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) M23-S335; R23-A125
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Mouse Interleukin-12 is produced by Human 293 Cells. The target gene encoding M23-S335; R23-A125 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	16160
UniProt ID	P43432
Synonyms	IL-12; Interleukin 12; Interleukin-12 subunit alpha;IL-12A;Cytotoxic lymphocyte maturation factor35 kDa subunit; CLMF p35;IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxiclymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
Summary	Interleukin-12 (IL-12) is a heterodimeric pleiotropic cytokine that consists of IL12A (p35) and IL12B (p40) subunits. IL?12 is expressed by macrophages and B lymphocytes and act as a growth factor for activated T and NK cells, help enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Studies have shown that IL?12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been predicted that IL?12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.