Interferon gamma (IFNG) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Q24-G161
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human Interferon gamma is produced by Human 293 Cells. The target gene encoding Q24-G161 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	3458
UniProt ID	P01579
Synonyms	Interferon-gamma; Interferon-?; IFNG
Summary	Interferon-gamma (IFN-gamma) is a secreted protein that belongs to the type II class of interferon. IFN-gamma is produced primarily by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN-gamma plays broader roles in the activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen presentation. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects.
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

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