NKG2C (KLRC2) Human Recombinant Protein
CAT#: TP724625
Recombinant Human NKG2C & CD94 Heterodimer
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
E98-L231; S34-I179
|
Tag | N-8His&N-FLAG |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human NKG2C/CD94 is produced by Human 293 Cells. The target gene encoding E98-L231&; S34-I179 is expressed with a 8His &; a FLAG tag at the N terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3822 |
UniProt ID | P26717 |
Synonyms | NKG2C & CD94 |
Summary | NKG2-C contains C-type lectin domain and belongs to the killer cell lectin-like receptor (KLR) family. KLR family is a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94, also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of NK cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I Human Leukocyte Antigen (HLA)-E molecules by NK cells and some cytotoxic T-cells. CD94 can form disulfide-bonded heterodimer with NKG2C on the surface of NK cells. The CD94/NKG2C complex interacts with HLA-E on target cells and inhibit the cytotoxic activity of NK cells to prevent cell lysis. |
Protein Families | Transmembrane |
Protein Pathways | Antigen processing and presentation, Natural killer cell mediated cytotoxicity |
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