PAK1 (NM_001128620) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) GPHPSDEEIL EKLRSIVSVG DPKKKYTRFE KIGQGASGTV YTAMDVATGQ EVAIKQMNLQ QQPKKELIIN EILVMRENKN PNIVNYLDSY LVGDELWVVM EYLAGGSLTD VVTETCMDEG QIAAVCRECL QALEFLHSNQ VIHRDIKSDN ILLGMDGSVK LTDFGFCAQI TPEQSKRSTM VGTPYWMAPE VVTRKAYGPK VDIWSLGIMA IEMIEGEPPY LNENPLRALY LIATNGTPEL QNPEKLSAIF RDFLNRCLEM VEKRGSAKEL LQHQFLKIAK PLSSLTPLIA AAKEATKNNH
Tag	Tag Free
Predicted MW	33.6 kDa
Concentration	lot specific
Purity	>90% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Storage	Store at -80°C.
Stability	Stable at -80°C for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -80°C.
Bioactivity	Specific activity was determined as 32,638 pmoles/min/µg, according to the Zlyte assay protocol
Endotoxin	< 0.1 ng/µg of protein (< 1EU/µg)
Reference Data
RefSeq	NP_001122092
Locus ID	5058
UniProt ID	Q13153
Cytogenetics	11q13.5-q14.1
Refseq ORF	1659
Synonyms	alpha-PAK; IDDMSSD; p65-PAK; PAKalpha
Summary	This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways	Axon guidance, Chemokine signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway

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