TIMP1 (NM_003254) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Human TIMP-1, the region of Cys24-Ala207, from gene Accession# NP_003245.1
Tag	C-His
Predicted MW	22 kDa
Concentration	lot specific
Purity	>90%, as determined by Coomassie stained SDS-PAGE.
Buffer	10 mM sodium Acetate, 150 mM NaCl, pH 5.0
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	Human TIMP-1 inhibits the activity of activated mouse MMP-9 (100 ng/mL). The is IC50 = 34 ng/mL.
Endotoxin	Less than 1.0 EU per µg of protein as determine by the LAL method
Reference Data
RefSeq	NP_003245
Locus ID	7076
UniProt ID	P01033
Refseq Size	931
Cytogenetics	Xp11.3
Refseq ORF	621
Synonyms	CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein

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