Il34 (NM_001135100) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Mouse IL-34, the region of Met1- Pro235, from gene Accession# NM_001135100.1
Tag	C-His
Predicted MW	26 kDa
Concentration	lot specific
Purity	>98%, as determined by Coomassie stained SDS-PAGE.
Buffer	10 mM NaH2PO4, 0.5 M NaCl, pH 7.4
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	The ED50 is 20 - 30 ng/ml, corresponding to a specific activity of 3.3 - 5 x 10^4 units/mg, determined by M-NFS-60 cell proliferation induction in a dose dependent manner.
Endotoxin	Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq	NP_001128572
Locus ID	76527
UniProt ID	Q8R1R4
Refseq Size	1747
Cytogenetics	8 E1
Refseq ORF	708
Synonyms	2010004A03Rik; AI593503
Summary	Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).[UniProtKB/Swiss-Prot Function]

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