Tnf (NM_013693) Mouse Recombinant Protein
CAT#: TP723743
Purified recombinant protein of Mouse tumor necrosis factor (Tnf)
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CNY 4,090.00
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Specifications
Product Data | |
Species | Mouse |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Mouse TNF-alpha;, the region of Leu80-Leu235, from gene Accession# NM_013693
|
Tag | Tag Free |
Predicted MW | 17.3 kDa |
Concentration | lot specific |
Purity | Purity is >98%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 10 mM NaH2PO4, 150 mM NaCl, pH 7.2 |
Storage | Store at -80°C. |
Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Bioactivity | The ED50 is 0.010-0.020 ng/ml, corresponding to a specific activity of 5-10 X10^7 units/mg, determined by a dose dependent stimulation of L929 cells treated with actinomycin D. |
Endotoxin | Less than 0.01 ng per ug protein as determined by the LAL method |
Reference Data | |
RefSeq | NP_038721 |
Locus ID | 21926 |
UniProt ID | P06804, Q3U593 |
Refseq Size | 1619 |
Cytogenetics | 17 18.59 cM |
Refseq ORF | 705 |
Synonyms | DI; DIF; Tn; TNF-; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfs; Tnfsf1a; TNFSF2; Tnlg1f |
Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
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