FGF8 (NM_033163) Human Recombinant Protein
CAT#: TP723101
Purified recombinant protein of Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant F.
View other "FGF8" proteins (4)
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CNY 4,030.00
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
|
Tag | Tag Free |
Predicted MW | 22.5 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 µM filtered solution of 20 mM phosphate buffer, 100 mM NaCl, pH 7.2 |
Storage | Store at -80°C. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Bioactivity | Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 5 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg. |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Reference Data | |
RefSeq | NP_149353 |
Locus ID | 2253 |
UniProt ID | P55075 |
Refseq Size | 1107 |
Cytogenetics | 10q24.32 |
Refseq ORF | 732 |
Synonyms | AIGF; FGF-8; HBGF-8; HH6; KAL6 |
Summary | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes
,Kent, OA;Saha, M;Coyaud, E;Burston, HE;Law, N;Dadson, K;Chen, S;Laurent, EM;St-Germain, J;Sun, RX;Matsumoto, Y;Cowen, J;Montgomery-Song, A;Brown, KR;Ishak, C;Rose, J;De Carvalho, DD;He, HH;Raught, B;Billia, F;Kannu, P;Rottapel, R;,
Nat Commun
,PubMed ID 32938917
[FGF8]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC409684 | FGF8 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY409684 | Transient overexpression lysate of fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant F |
CNY 3,080.00 |
|
TP760865 | Purified recombinant protein of Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant F, full length, with N-terminal HIS tag, expressed in E. coli, 50ug |
CNY 2,040.00 |
|
TP761728 | Purified recombinant protein of Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant A, full length, with N-terminal His tag, expressed in E. coli, 50ug |
CNY 2,040.00 |