CD38 Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Val43-Ile300
Tag	C-His
Predicted MW	The protein has a predicted molecular weight of 31.5kDa and migrates at approximately 35-45kDa on SDS-PAGE with DTT-reduced condition before APC conjugation.
Concentration	25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration.
Purity	>90%
Conjugation	APC
Buffer	1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein
Preparation	Affinity Ni-NTA
Applications	FACS
Storage	An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles.
Stability	6 Months
Bioactivity	Positive The definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test.
Reference Data
RefSeq	NP_001766.2
Locus ID	952
UniProt ID	P28907
Summary	Cluster of differentiation 38 (CD38) is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed in many immune cells including B cells, T lymphocytes, and NK cells. CD38 is expressed at high levels in some organs like pancreas, liver, kidney, brain, testis, ovary. CD38 can function as either a cell surface receptor or as an enzyme. As the receptor, CD38 can activate T cells and promote cytokine production. As the multifunctional enzyme, CD38 can regulating calcium mediated signal transduction through the production of cyclic ADP-ribose (cADPR) in many types of cells. Clinically, elevated CD38 expression is prognostic marker in chronic lymphocytic leukemia.
Protein Families	FACS
Protein Pathways	Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism

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