Tnfrsf1a (NM_011609) Mouse Recombinant Protein

Specifications

Product Data
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ile22-Ala212
Tag	Tag Free
Predicted MW	21.2 kDa
Concentration	lot specific
Purity	>95% as determined by SDS-PAGE and Coomassie blue staining
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Endotoxin	Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq
Locus ID	21937
UniProt ID	P25118
Cytogenetics	6 59.32 cM
Synonyms	CD120; CD120a; FPF; p5; p55; p55-R; TN; Tnf; TNF-; TNF-a; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFal; TNFalpha-R1; TNFAR; TNFR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55
Summary	This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]

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