GCDH (NM_000159) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Arg45-Lys438
Tag	N-His
Predicted MW	45 kDa
Purity	>95% as determined by SDS-PAGE and Coomassie blue staining
Buffer	Supplied as a 0.2 um filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.
Storage	Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability	Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Endotoxin	Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq
Locus ID	2639
UniProt ID	Q92947
Cytogenetics	19p13.13
Synonyms	ACAD5; GCD
Summary	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]
Protein Families	Druggable Genome
Protein Pathways	Fatty acid metabolism, Lysine degradation, Metabolic pathways, Tryptophan metabolism

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