Thymidylate Synthase (TYMS) (NM_001071) Human Recombinant Protein
CAT#: TP710029
Recombinant protein of human thymidylate synthetase (TYMS), full length, with N-terminal polyhistidine tag, expressed in sf9 cells.
View other "Thymidylate Synthase" proteins (4)
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CNY 4,020.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Species | Human |
Expression Host | Sf9 |
Expression cDNA Clone or AA Sequence |
A DNA sequence from TrueORF clone, RC204814, encoding human full-length TYMS
|
Tag | N-His |
Predicted MW | 36 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001062 |
Locus ID | 7298 |
UniProt ID | P04818, Q53Y97 |
Refseq Size | 1536 |
Cytogenetics | 18p11.32 |
Refseq ORF | 939 |
Synonyms | HST422; TMS; TS |
Summary | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC420700 | TYMS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY420700 | Transient overexpression lysate of thymidylate synthetase (TYMS) |
CNY 3,080.00 |
|
PH304814 | TYMS MS Standard C13 and N15-labeled recombinant protein (NP_001062) |
CNY 19,520.00 |
|
TP304814 | Recombinant protein of human thymidylate synthetase (TYMS), 20 µg |
CNY 2,900.00 |
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