Inhibin beta A (INHBA) (NM_002192) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence from TrueORF clone, RC203226, encoding the region Gly311-end of INHBA
Tag	Tag Free
Predicted MW	13.0 kDa
Concentration	>50 ug/mL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	Lyophilized from a 0.2 μm filtered solution of 4mM Hcl with trehalose as protectant.
Storage	Store at -20°C after receiving vials.
Stability	Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity	Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 1.84-5.53 ng/mL.
Reference Data
RefSeq	NP_002183
Locus ID	3624
UniProt ID	P08476, A4D1W7
Refseq Size	2175
Cytogenetics	7p14.1
Refseq ORF	1278
Synonyms	EDF; FRP
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

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