Uvssa (NM_001081101) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR218039 protein sequence Red=Cloning site Green=Tags(s) MDQKLSQLIEELTTSGESQLNAQKMKELKKICKSSEEQLSHAYRLLITQLTQGHAEIRLSAFQIVDELFT RSHQFRMLLVSDFQEFLELTLGTDSDRPLPPPREAAQRLRQAAMQAVEGWNEKFGQAYKKLALGYHFLKH TKKVDFRDINVRTVAERKREEEKQKHLDKIHRESADRAKREMEEMYDEIECCLTEVENCFKLLVPLDFVP CPEDKFFGEASSMTEGYAPCPLSPDLATPRESGLSGPQDEEQPCCSKDLVASAYHVGSVVGLKALPQTAM KDSSRDEDEPSDPDDFLRSHGLGSHKYTLDVEVPSDGLKVQENEDNLAVLHAARDSLKLIQNKFLPTVCS WVQRFTRAGTYSAHLKQAIDLKMELELALKKYEELNIEPGRGQRSRTEALEDSEDEDQDFVEVPEKEGYE PRIPDHLRAEYGLEPKAPLKTLEKGTAVCKLQERTRMRREEEASDPTSAAAQMLRLQDCLSSPSPSSTRV LPGPEEAQKQAERARAPIVPFGVDLCYWGQEQLTAGKILKSDSQHRFWKPSEVEEEVDSAHVSEMLHSRH ITFSGTFEPVQHKCRALRPNGRLCERQDRLKCPFHGKIIPRDDKGQPLNPEDRAREQRQQLQRQQAHPDW QDPEFLKDVEAATGVDLGSSRSSKKGKGKKKKHPNLTDLRERTNTARARLEKKVFAKAAVQRVVAAMNQM DQKKHEKFANQFNYALK TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	81.8 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001074570
Locus ID	71101
UniProt ID	Q9D479
Refseq Size	7343
Cytogenetics	5 B1
Refseq ORF	2154
Synonyms	4933407H18Rik; D330017J19Rik; Kiaa1530; mKIAA1530
Summary	Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).[UniProtKB/Swiss-Prot Function]

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