Sart3 (NM_016926) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR211322 representing NM_016926 Red=Cloning site Green=Tags(s) MATTAASSASEPEVEPQAGPEAEGEEDEAKPAGVQRKVLSGAVAAEAAEAKGPGWDLQREGASGSDGDEE DAMASSAESSAGEDEWEYDEEEEKNQLEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMS ELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSV FERALSSVGLHMTKGLAIWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYEMEATFAEYEEWSEEPMPE SVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIR YSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVE IWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNM QKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTL EDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDE ENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVGPPSKQKEKAASLKRDMPKVAHDSS KDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIV EGRPMFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKP KGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKPEVRTAPGAPMLPRQMYGARGKGR TQLSLLPRALQRQGAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLLRK TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	110.1 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_058622
Locus ID	53890
UniProt ID	Q9JLI8
Refseq Size	3586
Cytogenetics	5 F
Refseq ORF	2886
Synonyms	AU045857; mKIAA0156
Summary	U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (PubMed:21447833).[UniProtKB/Swiss-Prot Function]

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