Arhgap22 (BC038272) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR208068 protein sequence Red=Cloning site Green=Tags(s) MASSQRDMEDWVQAIRRVIWAPLGRGIFGQRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFR MPGQANLVRDLQDSFDCGEKPLFDRFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIMEGTSLV QHLMTVLIRKHGQLFAATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPTHRTSSLDGPAAAVLSRTS PPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGNWLINGLSSLRSHRR ASSGDRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSWSVASSSREASVSSCTACRASNSSACSSLHTE WALEPSPLPSSSEGHQSPDLGHSLDEPCVGSGSSEPNDPGSPTQAHVRRCRALQGQVAELRAELCQQRTE YKRSLKSIEEGSADLRKQMSRLEEELDQERKKYAMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGS LTTGTKGSRAPE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	55.1 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
Locus ID	239027
UniProt ID	Q8BL80
Refseq Size	2108
Cytogenetics	14 B
Refseq ORF	1506
Synonyms	MGC47316, RHOGAP2
Summary	Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.[UniProtKB/Swiss-Prot Function]

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