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G protein alpha S (GNAS) (NM_001077489) Human Recombinant Protein
CAT＃: TP316883
Purified recombinant protein of Homo sapiens GNAS complex locus (GNAS), transcript variant 7, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC216883 representing NM_001077489
Red=Cloning site Green=Tags(s) MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNG DEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWE DEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVG GQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQD LLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTC AVDTENIRRVFNDCRDIIQRMHLRQYELL TRRLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 44 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001070957 |
| Locus ID | 2778 |
| UniProt ID | P63092 |
| Refseq Size | 1881 |
| Cytogenetics | 20q13.32 |
| Refseq ORF | 1137 |
| Synonyms | AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PITA3; POH; SCG6; SgVI |
| Summary | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Long-term depression, Melanogenesis, Taste transduction, Vascular smooth muscle contraction, Vibrio cholerae infection |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC402577 | GNAS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC409171 | GNAS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421439 | GNAS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421440 | GNAS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC424674 | GNAS HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY402577 | Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 4 |
CNY 3,080.00 |
|
| LY409171 | Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 3 |
CNY 3,080.00 |
|
| LY421439 | Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 6 |
CNY 3,080.00 |
|
| LY421440 | Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 7 |
CNY 3,080.00 |
|
| LY424674 | Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 1 |
CNY 3,080.00 |
|
| PH314197 | GNAS MS Standard C13 and N15-labeled recombinant protein (NP_000507) |
CNY 19,520.00 |
|
| PH314318 | GNAS MS Standard C13 and N15-labeled recombinant protein (NP_536351) |
CNY 19,520.00 |
|
| PH316883 | GNAS MS Standard C13 and N15-labeled recombinant protein (NP_001070957) |
CNY 14,250.00 |
|
| TP314197 | Recombinant protein of human GNAS complex locus (GNAS), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
| TP314318 | Recombinant protein of human GNAS complex locus (GNAS), transcript variant 3, 20 µg |
CNY 2,900.00 |
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