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TNF alpha (TNF) (NM_000594) Human Recombinant Protein
CAT＃: TP306983
Recombinant protein of human tumor necrosis factor (TNF superfamily, member 2) (TNF), 20 µg
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| Cited in 3 publications. |
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC206983 protein sequence
Red=Cloning site Green=Tags(s) MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLI SPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLF KGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSA EINRPDYLDFAESGQVYFGIIAL TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 25.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Bioactivity | Cell treatment (PMID: 25406462) Cell treatment (PMID: 28057743) |
| Reference Data | |
| RefSeq | NP_000585 |
| Locus ID | 7124 |
| UniProt ID | P01375 |
| Refseq Size | 1686 |
| Cytogenetics | 6p21.33 |
| Refseq ORF | 699 |
| Synonyms | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F |
| Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020] |
| Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus |
Citations (3)
| The use of this Proteins has been cited in the following citations: |
|---|
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Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure
,Wang, W;Lu, H;Lu, X;Wang, D;Wang, Z;Dai, W;Wang, J;Liu, P;,
J Neuroinflammation
,PubMed ID 30134917
[TNF]
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IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts
,Bolzoni, M;Ronchetti, D;Storti, P;Donofrio, G;Marchica, V;Costa, F;Agnelli, L;Toscani, D;Vescovini, R;Todoerti, K;Bonomini, S;Sammarelli, G;Vecchi, A;Guasco, D;Accardi, F;Dalla Palma, B;Gamberi, B;Ferrari, C;Neri, A;Aversa, F;Giuliani, N;,
Haematologica
,PubMed ID 28057743
[TNF]
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Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential
,Adini, I;Adini, A;Bazinet, L;Watnick, RS;Bielenberg, DR;D'Amato, RJ;,
FASEB J.
,PubMed ID 25406462
[TNF]
|
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