FMO3 (NM_006894) Human Recombinant Protein
CAT#: TP306506
Recombinant protein of human flavin containing monooxygenase 3 (FMO3), transcript variant 1, 20 µg
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC206506 representing NM_006894
Red=Cloning site Green=Tags(s) MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFP DFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVF DAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQV MISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYMKQMNARFKHENYGLMPLNGVLRK EPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEI ILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWF GKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQW DRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 59.9 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_008825 |
Locus ID | 2328 |
UniProt ID | P31513, A0A024R8Z4, Q53FW5 |
Refseq Size | 2053 |
Cytogenetics | 1q24.3 |
Refseq ORF | 1596 |
Synonyms | dJ127D3.1; FMOII; TMAU |
Summary | Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016] |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Drug metabolism - cytochrome P450 |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC416335 | FMO3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC424145 | FMO3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
LY416335 | Transient overexpression lysate of flavin containing monooxygenase 3 (FMO3), transcript variant 1 |
CNY 3,080.00 |
|
LY424145 | Transient overexpression lysate of flavin containing monooxygenase 3 (FMO3), transcript variant 2 |
CNY 4,840.00 |
|
PH306506 | FMO3 MS Standard C13 and N15-labeled recombinant protein (NP_008825) |
CNY 19,520.00 |
|
PH312376 | FMO3 MS Standard C13 and N15-labeled recombinant protein (NP_001002294) |
CNY 19,520.00 |
|
TP312376 | Recombinant protein of human flavin containing monooxygenase 3 (FMO3), transcript variant 2, 20 µg |
CNY 2,900.00 |