Interleukin-2 / IL2 Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Predicted MW	15.4 kDa
Concentration	lot specific
Purity	>97% > 98% by SDS-PAGE and Silver staining
Buffer	Presentation State: Purified State: Lyophilized protein, without buffer and stabilizer
Preparation	Lyophilized protein, without buffer and stabilizer
Storage	Store lyophilized product at 2 - 8 °C for up to one month or at -20°C for longer. Following reconstitution store in aliquots at -20 °C. Avoid repeated freezing and thawing.
Stability	Shelf life: One year from despatch.
Bioactivity	Biological: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is 0.1-0.5 ng/ml. Specific: = 1 x 10e7 units/mg
Endotoxin	< 0.1 ng per µg of IL-2
Reference Data
RefSeq	NP_000577
Locus ID	3558
UniProt ID	P60568
Cytogenetics	4q27
Synonyms	IL-2, TCGF
Summary	This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

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