CD334 / FGFR4 (Fc Chimera) Human Protein

Specifications

Product Data
Species	Human
Expression Host	Insect
Predicted MW	170 kDa
Purity	>90% by SDS-PAGE and visualised by silver stain.
Buffer	Presentation State: Purified State: Lyophilized purifed protein. Buffer System: PBS withou stabilizers.
Preparation	Lyophilized purifed protein.
Protein Description	Recombinant Human soluble FGFR-4 was fused with the Fc-part of Human IgG1. Human recombinant soluble FGFR-4/Fc is a disulfide-linked heterodimeric protein. In the reduced form the glycosylated subunits of sFGFR-4 alpha/Human Fc chimera display a molecular mass of 80-85 kDa.
Note	Centrifuge vials before opening!
Storage	Store Lyophilized at -20°C to -70°C. Reconstituted sFGFR-4/Fc should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!
Stability	Shelf life: One year from despatch.
Bioactivity	Biological: Determined by its ability to inhibit Human FGF basic-dependent proliferation on HUVE cells. The ED50 for this effect is typically at 15-30 ng/ml.
Endotoxin	< 0.1 ng per µg of sFGFR-4.
Reference Data
RefSeq	NP_001278909
Locus ID	2264
UniProt ID	P22455
Cytogenetics	5q35.2
Synonyms	FGFR-4, JTK2, TKF
Summary	The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton

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