Angiopoietin-1 (21-496, His-tagged) Human Protein

Specifications

Product Data
Species	Human
Tag	His-tag
Predicted MW	60-67 kDa
Purity	>95% pure by SDS-PAGE and visualised by silver stain.
Buffer	Presentation State: Purified State: Lyophilized purified protein. Buffer System: 10 mM Sodium Phophate + 100 mM NaCl, pH 7.5
Preparation	Lyophilized purified protein.
Protein Description	Recombinant Human Angiopoietin-1, a 66 kDa protein consist ing of 476 amino acid residues (N21-F496), is fused to a C-terminal His-tag and produced in Hela cells.
Storage	Store Ang-1 undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: The biological activity was determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells.
Endotoxin	< 0.1 ng per µg of Ang-1
Reference Data
RefSeq	NP_001137
Locus ID	284
UniProt ID	Q15389
Cytogenetics	8q23.1
Synonyms	ANG-1, ANG1, ANGPT1, KIAA0003
Summary	This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

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