Glyoxalase I / GLO1 (1-184, His-tag) Mouse Protein
CAT#: AR52069PU-N
Glyoxalase I / GLO1 (1-184, His-tag) mouse protein, 50 µg
Size: 10 ug
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CNY 7,360.00
货期*
详询
规格
Cited in 3 publications. |
Specifications
Product Data | |
Species | Mouse |
Expression cDNA Clone or AA Sequence |
MAEPQPASSG LTDETAFSCC SDPDPSTKDF LLQQTMLRIK DPKKSLDFYT RVLGLTLLQK LDFPAMKFSL YFLAYEDKND IPKDKSEKTA WTFSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKI ATIILEHHHH HH
|
Tag | His-tag |
Predicted MW | 21.8 kDa |
Concentration | lot specific |
Purity | >95% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Preparation | Liquid purified protein |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Bioactivity | Specific: Specific activity is > 210 units/mg, and is defined as the amount of enzyme that will form 1.0 µmol of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 6.5 at 25C. |
Endotoxin | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_001107032 |
Locus ID | 109801 |
UniProt ID | Q9CPU0, A5GZX3 |
Cytogenetics | 17 15.69 cM |
Synonyms | 0610009E22Rik; 1110008E19Rik; 2510049H23Rik; AW550643; Glo-1; Glo-1r; Glo-1s; Glo1-r |
Summary | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.[UniProtKB/Swiss-Prot Function] |
Citations (3)
The use of this Proteins has been cited in the following citations: |
---|
Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control. Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 29504694
[Glo1]
|
Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB.
,null,
Free radical biology medicine
,PubMed ID 25841781
[Glo1]
|
Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2
,null,
PLoS ONE
,PubMed ID 23056421
[Glo1]
|
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