BMP7 Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCE GECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI S VLYFDDSSN VILKKYRNMV VRACGCH
Predicted MW	28.8 kDa
Purity	>98% by SDS-PAGE & HPLC analysis
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: PBS without stabilizers
Preparation	Lyophilized purified protein
Protein Description	Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.
Note	Centrifuge vials before opening!
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.
Endotoxin	< 0.1 ng per µg of BMP-7
Reference Data
RefSeq	NP_001710
Locus ID	655
UniProt ID	P18075
Cytogenetics	20q13.31
Synonyms	BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
Protein Pathways	Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway

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