AHA1 / AHSA1 (19-337) Human Protein
CAT#: AR09004PU-N
AHA1 / AHSA1 (19-337) human recombinant protein, 0.5 mg
Size: 100 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MATNVNNWHW TERDASNWST DKLKTLFLAV QVQNEEGKCE VTEVSKLDGE ASINNRKGKL IFFYEWSVKL NWTGTSKSGV QYKGHVEIPN LSDENSVDEV EISVSLAKDE PDTNLVALMK EEGVKLLREA MGIYISTLKT EFTQGMILPT MNGESVDPVG QPALKTEERK AKPAPSKTQA RPVGVKIPTC KITLKETFLT SPEELYRVFT TQELVQAFTH APATLEADRG GKFHMVDGNV SGEFTDLVPE KHIVMKWRFK SWPEGHFATI TLTFIDKNGE TELCMEGRGI PAPEEERTRQ GWQRYYFEGI KQTFGYGARL
|
Predicted MW | 36.1 kDa |
Concentration | lot specific |
Purity | >95% > / = 95% by SDS PAGE |
Buffer | Presentation State: Purified State: Liquid Buffer System: 20 mM Tris pH 8.0 , 2 mM EDTA |
Preparation | Liquid |
Protein Description | Recombinant Aha1 was expressed in E. coli and purified by using conventional chromatography techniques. |
Storage | Store at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001308370 |
Locus ID | 10598 |
UniProt ID | O95433, G3V438 |
Cytogenetics | 14q24.3 |
Synonyms | AHA1; C14orf3; hAha1; p38 |
Summary | Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).[UniProtKB/Swiss-Prot Function] |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport *
,null,
The Journal of Biological Chemistry
,PubMed ID 26872972
[AHSA1]
|
Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells
,null,
ACS Chemical Biology
,PubMed ID 25402753
[AHSA1]
|
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