Natriuretic peptides B (27-134, His-tag) Human Protein
CAT#: AR03036PU-N
Natriuretic peptides B (27-134, His-tag) human recombinant protein, 0.1 mg
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CNY 8,900.00
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规格
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MHPLGSPGSA SDLETSGLQE QRNHLQGKLS ELQVEQTSLE PLQESPRPTG VWKSREVATE GIRGHRKMVL YTLRAPRSPK MVQGSGCFGR KMDRISSSSG LGCKVLRRH
|
Tag | His-tag |
Predicted MW | 14 kDa |
Concentration | lot specific |
Purity | >90% by SDS-PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate-Buffered Saline (pH 7.4), 40% glycerol, 2 mM DTT, 0.1 mM PMSF, 1 mM EDTA |
Preparation | Liquid purified protein |
Protein Description | Recombinant human BNP, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Endotoxin | < 1.0 EU per 1 μg of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_002512 |
Locus ID | 4879 |
UniProt ID | P16860 |
Cytogenetics | 1p36.22 |
Synonyms | BNP; Iso-ANP |
Summary | This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020] |
Protein Families | Druggable Genome, Secreted Protein, Stem cell - Pluripotency |
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