Trypsin-1 / PRSS1 Human Protein

Specifications

Product Data
Description	Trypsin-1 / PRSS1 human protein, 0.1 mg
Species	Human
Protein Source	Pancreas
Concentration	lot specific
Purity	>95% pure by SDS-PAGE.
Buffer	Presentation State: Purified State: Lyophilized purified protein.
Bioactivity	Biological: Shows no chymotrypsin activity when assayed against N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-p-nitroanilide. Specific: >/= 2.5 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one µmole of N-Benzyl-L-arginine-pNA per minute at 25°C in 200 mM Tris-HCl, pH 7.8, 20 mM CaCl2.
Reconstitution	Restore with 80.8 µl 2mM HCl. Use product immediately after bringing to neutral pH to avoid auto-degradation.
Preparation	Lyophilized purified protein.
Protein Description	Human Trypsin
Note	Caution: All human source materials have tested non-reactive for HIV1, HIV2, HCV, HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Storage	Store lyophilized product at -20°C. After reconstitution, store at 2-8°C for up to two weeks. Long term, store at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_002760
Locus ID	5644
Cytogenetics	7q34
Synonyms	TRP1, TRY1, TRYP1, Trypsin I, Cationic trypsinogen, Beta-trypsin, Serine protease 1
Summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Neuroactive ligand-receptor interaction

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