Cathepsin G Human Protein

Specifications

Product Data
Description	Cathepsin G human protein, 0.1 mg
Species	Human
Protein Source	Neutrophils
Purity	>95% pure (SDS-PAGE)
Buffer	Presentation State: Purified State: Lyophilized purified fraction (>95% by SDS-PAGE) containing no preservatives.
Bioactivity	Biological (Lot dependent): 2-4 U/mg protein. One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-ala-ala-pro-phe-pNA (1mM) per minute at 25°C in 160 mM Tris HCl, pH 7.4 containing 1.6 M NaCl.
Reconstitution	Reconstitute with 86.2 µL using 50 mM Na Acetate, pH 5.5, with 150 mM Sodium Chloride as the buffer to be added to the salt-free lyophilized solid.
Preparation	Lyophilized purified fraction (>95% by SDS-PAGE) containing no preservatives.
Protein Description	Human Neutrophil Cathepsin G
Note	Caution: All human source materials have tested negative for HIV 1, HIV 2 and non-reactive for anti-HCV, HBsAg and anti-HBc. No test guarantees a product to be non-infectious. Therefore, all materials derived from human fluids or tissues should be considered as potentially infectious.
Storage	Store the antigen upon receipt at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: six months from despatch.
Reference Data
RefSeq	NP_001902
Locus ID	1511
Cytogenetics	14q12
Synonyms	CTSG, VSP
Summary	The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome, Neuroactive ligand-receptor interaction, Renin-angiotensin system, Systemic lupus erythematosus

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