Troponin I fast skeletal muscle (TNNI2) (NM_001145829) Human Mass Spec Standard

CAT#: PH327419

TNNI2 MS Standard C13 and N15-labeled recombinant protein (NP_001139301)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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Specifications

Product Data
Description TNNI2 MS Standard C13 and N15-labeled recombinant protein (NP_001139301)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC227419
Predicted MW 21.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001139301
RefSeq Size 746
RefSeq ORF 546
Synonyms AMCD2B; DA2B; DA2B1; FSSV; fsTnI
Locus ID 7136
Cytogenetics 11p15.5
Summary This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
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