Neurogranin (NRGN) (NM_001126181) Human Mass Spec Standard

Specifications

Product Data
Description	NRGN MS Standard C13 and N15-labeled recombinant protein (NP_001119653)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC224996
Predicted MW	7.6 kDa
Protein Sequence	Sequence Link (showhide) >RC224996 protein sequence Red=Cloning site Green=Tags(s) MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGG AGGGPSGD TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001119653
RefSeq Size	1238
RefSeq ORF	234
Synonyms	hng; RC3
Locus ID	4900
Cytogenetics	11q24.2
Summary	Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome

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