TORC1 (CRTC1) (NM_001098482) Human Mass Spec Standard

CAT#: PH324693

CRTC1 MS Standard C13 and N15-labeled recombinant protein (NP_001091952)



  View other "TORC1" proteins (7)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Description CRTC1 MS Standard C13 and N15-labeled recombinant protein (NP_001091952)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC224693
Predicted MW 68.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001091952
RefSeq Size 7009
RefSeq ORF 1950
Synonyms Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1
Locus ID 23373
Cytogenetics 19p13.11
Summary Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.[UniProtKB/Swiss-Prot Function]
Protein Families Transcription Factors
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