SCN4B (NM_174934) Human Mass Spec Standard

Specifications

Product Data
Description	SCN4B MS Standard C13 and N15-labeled recombinant protein (NP_777594)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC223951
Predicted MW	22 kDa
Protein Sequence	Sequence Link (showhide) >RC223951 representing NM_174934 Red=Cloning site Green=Tags(s) MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTY NSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENN LQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDN TENGLPGSKAEEKPPSKV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_777594
RefSeq Size	4489
RefSeq ORF	684
Synonyms	ATFB17; LQT10; Navbeta4
Locus ID	6330
Cytogenetics	11q23.3
Summary	The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Protein Families	Ion Channels: Sodium, Transmembrane

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