Proprotein Convertase 2 (PCSK2) (NM_002594) Human Mass Spec Standard

CAT#: PH322498

PCSK2 MS Standard C13 and N15-labeled recombinant protein (NP_002585)



  View other "Proprotein Convertase 2" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of proprotein convertase subtilisin/kexin type 2 (PCSK2)
    • 100 ug

CNY 4,840.00


Rabbit polyclonal PCSK2 Antibody (N-term)
    • 400 ul

CNY 6,160.00

Specifications

Product Data
Description PCSK2 MS Standard C13 and N15-labeled recombinant protein (NP_002585)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222498
Predicted MW 70.57 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002585
RefSeq Size 4745
RefSeq ORF 1914
Synonyms NEC-2; NEC 2; NEC2; PC2; SPC2
Locus ID 5126
Cytogenetics 20p12.1
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Protein Families Druggable Genome, Protease, Secreted Protein
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